O'Malley, D,Dinan, TG,Cryan, JF;

2011

January

The Journal of Immunology

Altered expression and secretion of colonic Interleukin-6 in a stress-sensitive animal model of brain-gut axis dysfunction

Validated

()

Interleukin-6 Irritable bowel syndrome Submucosal neurons Wistar Kyoto rat IRRITABLE-BOWEL-SYNDROME ENTERIC NERVOUS-SYSTEM IL-6 EXCITE NEURONS VISCERAL HYPERSENSITIVITY MATERNAL SEPARATION INTERFERON-GAMMA GUINEA-PIG RATS BEHAVIOR RECEPTORS

235

48

55

Interleukin-6 (IL-6) can activate gastrointestinal submucosal neurons, with associated implications for motility and secretory function. Patients with irritable bowel syndrome (IBS) have elevated levels of circulating IL-6. Colons from the Wistar Kyoto (WKY) rat model of IBS secrete more IL-6 (12.84 pg/ml) than control Sprague Dawley (SD) colons (5.55 pg/ml) and WKY secretions stimulated calcium responses in naive submucosal neurons of greater amplitude. Recombinant IL-6 activated more submucosal neurons in WKY tissue preparations (p<0.05). These data demonstrate that WKY colonic supernatants activate submucosal neurons using an IL-6-dependent mechanism, thereby providing a link between gastrointestinal dysfunction and alterations in IL-6 levels. (C) 2011 Elsevier B.V. All rights reserved.

DOI 10.1016/j.jneuroim.2011.04.003