Peer-Reviewed Journal Details
Mandatory Fields
McCarthy, F. O. and Chopra, J. and Ford, A. and Hogan, S. A. and Kerry, J. P. and O'Brien, N. M. and Ryan, E. and Maguire, A. R.
Organic & Biomolecular Chemistry
Synthesis, isolation and characterisation of beta-sitosterol and beta-sitosterol oxide derivatives
Optional Fields
beta-Sitosterol is the most prevalent plant cholesterol derivative (phytosterol) and can undergo similar oxidation to cholesterol, leading to beta-sitosterol oxides. The biological impact of phytosterol oxides has only been evaluated in a phytosterol blend (usually of beta-sitosterol, campesterol, stigmasterol and dihydrobrassicasterol). The lack of pure phytosterols, including beta-sitosterol, hinders the collection of significant toxicity data on the individual beta-sitosterol oxides. An efficient synthetic route to multi-gram quantities of pure beta-sitosterol is described here, together with the first syntheses and characterisation of pure beta-sitosterol oxides.
Grant Details