Peer-Reviewed Journal Details
Mandatory Fields
O'Sullivan JF, Leblond AL, Kelly G, Kumar AH, Metharom P, B√ľneker CK, Alizadeh-Vikali N, Hristova I, Hynes BG, O'Connor R, Caplice NM
2011
August
Circulation. Cardiovascular interventions
Potent long-term cardioprotective effects of single low-dose insulin-like growth factor-1 treatment postmyocardial infarction.
Validated
Optional Fields
4
4
327
335
Insulin-like growth factor-1 (IGF-1) is recognized as an important regulator of cardiac structure and cardiomyocyte homeostasis. The prosurvival and antiapoptotic effects of IGF-1 have been investigated in vitro and in rodent models of myocardial infarction (MI). However, the clinical application of IGF-1 has been hampered by dose-dependent side effects both acutely and during chronic administration. We hypothesized that single, low-dose IGF-1 (LD-IGF-1) administered locally and early in the reperfusion phase after acute MI in a large animal model would avoid significant side effects but would have prosurvival effects that would manifest in long-term structural and functional improvement after MI treatment.
10.1161/CIRCINTERVENTIONS.110.960765
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