Peer-Reviewed Journal Details
Mandatory Fields
Draper S.J, Moore A.C., Goodman A.L., Long C.A., Holder A.A., Gilbert S.C., Hill F., Hill A.V.S.;
2008
January
Nature Medicine
Multi-Stage Protection against Malaria using Recombinant Viral Vaccines Expressing Merozoite Surface Protein-1.
Published
Optional Fields
14
819
821
Protein-in-adjuvant vaccines have shown limited success against difficult diseases such as blood-stage malaria. Here we show that a recombinant adenovirus-poxvirus prime-boost immunization regime (known to induce strong T cell immunogenicity) can also induce very strong antigen-specific antibody responses, and we identify a simple complement-based adjuvant to further enhance immunogenicity. Antibodies induced against a blood-stage malaria antigen by this viral vector platform are highly effective against Plasmodium yoelii parasites in mice and against Plasmodium falciparum in vitro.
http://www.nature.com/nm/journal/v14/n8/abs/nm.1850.html
10.1038/nm.1850
Grant Details