Peer-Reviewed Journal Details
Mandatory Fields
O'Mahony GE, Ford A, Maguire AR
2012
March
The Journal of Organic Chemistry
Copper-Catalyzed Asymmetric Oxidation of Sulfides.
Published
Optional Fields
Copper-catalyzed asymmetric sulfoxidation of aryl benzyl and aryl alkyl sulfides, using aqueous hydrogen peroxide as the oxidant, has been investigated. A relationship between the steric effects of the sulfide substituents and the enantioselectivity of the oxidation has been observed, with up to 93% ee for 2-naphthylmethyl phenyl sulfoxide, in modest yield in this instance (up to 30%). The influence of variation of solvent and ligand structure was examined, and the optimized conditions were then used to oxidize a number of aryl alkyl and aryl benzyl sulfides, producing sulfoxides in excellent yields in most cases (up to 92%), and good enantiopurities in certain cases (up to 84% ee).
10.1021/jo2026178
Grant Details