Slattery, CN,Clarke, LA,O'Neill, S,Ring, A,Ford, A,Maguire, AR

2012

January

Synlett

Investigation of Additive Effects in Enantioselective Copper-Catalysed C-H Insertion and Aromatic Addition Reactions of alpha-Diazocarbonyl Compounds

Published

()

diazocarbonyl copper catalysis C-H insertion Buchner reaction bis(oxazoline) ligands CARBENE INSERTION BONDS COMPLEXES

765

767

Significant enhancements in enantioselectivities and reaction efficiencies in asymmetric copper-catalysed C-H insertion and aromatic addition reactions of alpha-diazocarbonyl compounds in the presence of various group I salts are reported. For the first time in carbenoid chemistry, evidence for the critical role of the metal cation is described.

DOI 10.1055/s-0031-1290598