Maguire, NM,Ford, A,Clarke, SL,Eccles, KS,Lawrence, SE,Brossat, M,Moody, TS,Maguire, AR

2011

January

Tetrahedron-Asymmetry

A practical chemo-enzymatic approach to highly enantio-enriched cyanohydrin acetates

Validated

()

CATALYZED KINETIC RESOLUTION RACEMIC CYANOHYDRINS BUILDING-BLOCKS CANDIDA-RUGOSA LIPASE ESTERIFICATION ESTERS

22

2144

2150

The preparation of enantiopure cyanohydrin acetates via enzymatic hydrolysis has been investigated by screening a range of biocatalysts and reaction conditions. Enzymatic resolution has been optimised through variation of the hydrolase biocatalyst and reaction conditions leading to synthetically useful routes to enantiopure cyanohydrin acetates. (C) 2011 Elsevier Ltd. All rights reserved.

DOI 10.1016/j.tetasy.2011.11.022