Metharom P, Martin K, Kumar AH, Sawhney N, Cronin MF, McCarthy DG, Maguire AR, Caplice NM

2011

May

Atherosclerosis

Pleiotropic role for monocyte C-fms protein in response to vascular injury: potential therapeutic target.

Validated

()

216

1

74

82

We examined the role of C-fms+ cells in response to vascular injury with a focus on the temporal and spatial platelet interactions, monocyte survival and proliferation within the evolving neointimal lesion and monocyte proliferation within the circulation and specified monocyte reservoir sites. Finally, we investigated the therapeutic effect of C-fms kinase inhibition (CFKI) on neointimal hyperplasia post vessel injury.

10.1016/j.atherosclerosis.2011.01.037