Draper, LA,Tagg, JR,Hill, C,Cotter, PD,Ross, RP

2012

January

Antimicrobial Agents and Chemotherapy

The spiFEG Locus in Streptococcus infantarius subsp infantarius BAA-102 Confers Protection against Nisin U

Validated

()

GRAM-POSITIVE PATHOGENS LACTOCOCCUS-LACTIS LISTERIA-MONOCYTOGENES LANTIBIOTIC NISIN INNATE RESISTANCE GENE-CLUSTER IMMUNITY BIOSYNTHESIS IDENTIFICATION ANTIBIOTICS

56

573

578

Nisin U is a member of the extended nisin family of lantibiotics. Here we identify the presence of nisin U immunity gene homologues in Streptococcus infantarius subsp. infantarius BAA-102. Heterologous expression of these genes in Lactococcus lactis subsp. cremoris HP confers protection to nisin U and other members of the nisin family, thereby establishing that the recently identified phenomenon of resistance through immune mimicry also occurs with respect to nisin.

DOI 10.1128/AAC.05778-11