Peer-Reviewed Journal Details
Mandatory Fields
Coffey, JC,Smith, MJF,Wang, JH,Bouchier-Hayes, D,Cotter, TG,Redmond, HP
2006
April
Bioessays
Cancer surgery: risks and opportunities
Validated
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Optional Fields
EARLY BREAST-CANCER TUMOR-GROWTH CYTOREDUCTIVE SURGERY PERIOPERATIVE CHEMOTHERAPY LAPAROSCOPIC SURGERY COLONIC ANASTOMOSES CURATIVE RESECTION ASSISTED COLECTOMY MAMMARY-CARCINOMA METASTASES
28
433
437
In the recent past, several papers have pointed to the possibility that tumour removal generates a permissive environment in which tumour growth is potentiated. This phenomenon has been coined "perioperative tumour growth" and whilst it represents a departure in terms of our attitude to the surgical process, this concept was first hinted at by Paget(1) himself. Despite this, the time interval immediately before and after cancer surgery (i.e. the perioperative period) remains an underutilised interval during which chemotherapeutic regimens are rarely implemented. Herein, we present a summarised review of the literature that supports the concept that tumour removal may potentiate the growth of residual neoplastic disease. We also outline current knowledge regarding underlying mechanisms and in this manner highlight potential therapeutic entry points. Finally, we emphasise the urgent need for trials of agents that could protect patients against the harmful host-tumour interactions that may occur during the perioperative period.
DOI 10.1002/bies.20381
Grant Details