Pouchitis
Etiology
Management
INFLAMMATORY-BOWEL-DISEASE
FAMILIAL ADENOMATOUS POLYPOSIS
QUALITY-OF-LIFE
ULCERATIVE-COLITIS PATIENTS
SULFATE-REDUCING BACTERIA
POLYPEPTIDE-IMMUNOREACTIVE INNERVATION
ANTINEUTROPHIL CYTOPLASMIC ANTIBODY
VSLNUMBER-3 PROBIOTIC MIXTURE
CHRONIC REFRACTORY POUCHITIS
PELVIC ILEAL RESERVOIR
While the overall incidence of pouchitis is low, extensive research continues at clinical and experimental levels in attempts to unravel its etiology. The ileal pouch and pouchitis together represent a unique in vivo opportunity to study mucosal adaptation and inflammation in depth. In the recent past, molecular data relating to pouchitis has significantly expanded. These data provide invaluable insight into intracellular and extracellular events that underpin mucosal adaptation and inflammation. Advances in classification, risk factor evaluation, and prevention have meant that a review of this data, as well as its relationship to our current understanding of pouchitis, is both timely and warranted. Therefore, the aim of this review is to summarize recent data in the context of the established literature.