Book Reviews

Allen, EM,Matthews, JB,O'Connor, R,O'Halloran, D,Chapple, ILC

2009

May

Periodontitis and Type 2 Diabetes: Is Oxidative Stress the Mechanistic Link?

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Diabetes periodontitis oxidative stress inflammation TOTAL ANTIOXIDANT CAPACITY NF-KAPPA-B HUMAN POLYMORPHONUCLEAR LEUKOCYTES POOR GLYCEMIC CONTROL ALPHA-LIPOIC ACID PROTEIN-KINASE-C REACTIVE OXYGEN INSULIN-RESISTANCE CARDIOVASCULAR-DISEASE CREVICULAR FLUID

Periodontitis is a common, chronic inflammatory disease initiated by bacteria which has an increased prevalence and severity in patients with type 2 diabetes. Recent studies indicate that the co-morbid presence of periodontitis can, in turn. adversely affect diabetic status and the treatment of periodontitis can lead to improved metabolic control in diabetes patients. Current evidence points to a bidirectional interrelationship between diabetes and inflammatory periodontitis. The importance of oxidative stress-inflammatory pathways in the pathogenesis of type 2 diabetes and periodontitis has recently received attention. Given the bidirectional relationship between these two conditions, this review discusses the potential synergistic interactions along the oxidative stress-inflammation axis common to both type 2 diabetes and periodontitis, and the implications of this relationship for diabetic patients.

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