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Book Reviews
Cotter, TG
2009
January
Apoptosis and cancer: the genesis of a research field
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TUMOR-NECROSIS-FACTOR APO-1/FAS RECEPTOR/LIGAND SYSTEM DRUG-INDUCED APOPTOSIS BCL-2 FAMILY PROTEINS B-CELL LYMPHOMA WILD-TYPE P53 C-MYC PROGNOSTIC-SIGNIFICANCE BREAST-CANCER MONOCLONAL-ANTIBODY
In multicellular organisms, the total number of cells is a balance between the cell-generating effects of mitosis and cell death that is induced through apoptosis. A disruption of this delicate balance can lead to the development of cancer. This Timeline article focuses on how the field of apoptosis biology has developed in the context of its contribution to our understanding of cell death, or lack of it, in the development of malignant disease. It traces the course of research from key discoveries in fundamental biology to potential therapeutic applications.
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DOI 10.1038/nrc2663
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