Peer-Reviewed Journal Details
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Cashman, KD,O'Connor, E
2008
August
Nutrition Reviews
Does high vitamin K-1 intake protect against bone loss in later life?
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bone health intervention studies later life phylloquinone vitamin K-1 SERUM UNDERCARBOXYLATED OSTEOCALCIN MINERAL DENSITY K STATUS HIP FRACTURE POSTMENOPAUSAL WOMEN ELDERLY-WOMEN HEALTH PHYLLOQUINONE OSTEOPOROSIS RISK
66
532
538
The findings of a number of cross-sectional studies suggest benefits of high phylloquinone (vitamin K-1) intake on bone health in later life. Until recently these observational data were supported by the findings of an intervention study that showed a protective role for vitamin K-1 (together with calcium, magnesium, zinc, and vitamin D-3) on bone loss over 3 years in early postmenopausal women. Over the last 18 months, two further important intervention studies have been published, which investigated the effect of vitamin K-1 on bone loss in older subjects. These two studies add to the evidence-base but cast some doubt on the benefits of high vitamin K-1 intake on bone health in later life. (C) 2008 International Life Sciences Institute.
DOI 10.1111/j.1753-4887.2008.00086.x
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