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Guerin, MB,McKernan, DP,O'Brien, CJ,Cotter, TG
2006
June
Retinal ganglion cells: dying to survive
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BCL-2 FAMILY-MEMBERS NERVE GROWTH-FACTOR CYTOCHROME-C NEUROTROPHIC FACTOR CASPASE ACTIVATION BH3-ONLY PROTEINS VERTEBRATE RETINA CHICK RETINA OPTIC-NERVE SUPERIOR COLLICULUS
This review examines the maturation of the retinal ganglion cell (RGC) population within the nascent retina. Apoptosis, a form of programmed cell death prevalent throughout the developing central nervous system (CNS), is evident in the growth of RGCs within the ganglion cell layer. These cells provide an accessible and illuminating platform to elucidate the apoptotic pathways present in the developing CNS and the role this form of cell death plays in RGC growth. This article focuses on the seminal stages of RGC development and the role played by neurotrophic factors and apoptosis in this process.
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674
DOI 10.1384/ijdb.062159mg
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