Parkkinen L, O'Sullivan SS, Kuoppamäki M, Collins C, Kallis C, Holton JL, Williams DR, Revesz T, Lees AJ

2011

October

Urology

Does levodopa accelerate the pathologic process in Parkinson disease brain?

Validated

Altmetric: 9 ()

77

15

1420

1426

Several in vitro studies have suggested levodopa (L-dopa) to be toxic to dopaminergic neurons and that it can modulate the aggregation process of α-synuclein. We investigated the relationship between cumulative lifetime dose of l-dopa and nigral neuronal count and Lewy body (LB) pathology in Parkinson disease (PD).

10.1212/WNL.0b013e318232ab4c