Abbas, A.,Adams, C.,Scully, N.,Glennon, J.,O'Gara, F.;

2007

September

Fems Microbiology Letters

A role for TonB1 in biofilm formation and quorum sensing in Pseudomonas aeruginosa. Fems Microbiology Letters

Validated

()

274

2

269

278

This study revealed that a Pseudomonas aeruginosa tonB1 mutant was unable to produce a mature biofilm and showed reduced swarming and twitching motilities compared with the parent strain. The tonB1 mutant was also found to produce significantly lower cell-free and cell-associated levels of the quorum sensing (QS) signal molecule 3-oxo-C12-AHL. Altered biofilm and motility phenotypes were restored to wildtype with the addition of exogenous N-acylhomoserine lactones. These functions were independent of the role of TonB1 in iron uptake. This is the first time that a link has been established between TonB1 activity and QS.

0378-1097

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