Peer-Reviewed Journal Details
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Long-Smith, C.M., Collins, L., Toulouse, A., Sullivan, A.M., Nolan Y.M.
2010
September
Journal of Neuroimmunology
Interleukin-1 beta contributes to dopaminergic neuronal death induced by lipopolysaccharide-stimulated rat glia in vitro.
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226
1-2
20
26
Inflammation is involved in the pathology of Parkinson's disease, a disorder characterised by degeneration of dopaminergic neurons. This study demonstrates that conditioned medium (CM) from lipopolysaccharide (LPS)-treated rat glial-enriched cortical cultures induced death of embryonic rat dopaminergic neurons in vitro, an effect which was additive to the toxicity of the neurotoxin 6-hydroxydopamine. Interleukin-1 (IL-1) in the CM may mediate this neuronal death. IL-1R1 was found to be expressed on dopaminergic neurons. Blockade of IL-1R1 prevented CM-induced dopaminergic neuronal death. This study suggests that IL-1 in CM from LPS-stimulated glia contributes to dopaminergic neuronal death induced by glia-conditioned medium.
10.1016/j.jneuroim.2010.05.030
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