Long-Smith, C.M., Collins, L., Toulouse, A., Sullivan, A.M., Nolan Y.M.

2010

September

Journal of Neuroimmunology

Interleukin-1 beta contributes to dopaminergic neuronal death induced by lipopolysaccharide-stimulated rat glia in vitro.

Validated

()

226

1-2

20

26

Inflammation is involved in the pathology of Parkinson's disease, a disorder characterised by degeneration of dopaminergic neurons. This study demonstrates that conditioned medium (CM) from lipopolysaccharide (LPS)-treated rat glial-enriched cortical cultures induced death of embryonic rat dopaminergic neurons in vitro, an effect which was additive to the toxicity of the neurotoxin 6-hydroxydopamine. Interleukin-1ß (IL-1ß) in the CM may mediate this neuronal death. IL-1R1 was found to be expressed on dopaminergic neurons. Blockade of IL-1R1 prevented CM-induced dopaminergic neuronal death. This study suggests that IL-1ß in CM from LPS-stimulated glia contributes to dopaminergic neuronal death induced by glia-conditioned medium.

10.1016/j.jneuroim.2010.05.030