Peer-Reviewed Journal Details
Mandatory Fields
Mac Aogain, M,Mooij, MJ,McCarthy, RR,Plower, E,Wang, YP,Tian, ZX,Dobson, A,Morrissey, J,Adams, C,O'Gara, F
2012
January
Microbiology-SGM
The non-classical ArsR-family repressor PyeR (PA4354) modulates biofilm formation in Pseudomonas aeruginosa
Validated
()
Optional Fields
YELLOW ENZYME FAMILY PLANT-ASSOCIATED BACTERIA ESCHERICHIA-COLI OPERON SEQUENCE METAL RESISTANCE MUTAGENESIS TOXICITY DATABASE
158
2598
2609
PyeR (PA4354) is a novel member of the ArsR family of transcriptional regulators and modulates biofilm formation in Pseudomonas aeruginosa. Characterization of this regulator showed that it has negative autoregulatory properties and binds to a palindromic motif conserved among PyeR orthologues. These characteristics are in line with classical ArsR-family regulators, as is the fact that PyeR is part of an operon structure (pyeR-pyeM-xenB). However, PyeR also exhibits some atypical features in comparison with classical members of the ArsR family, as it does not harbour metal-binding motifs and does not appear to be involved in metal perception or resistance. Hence, PyeR belongs to a subgroup of non-classical ArsR-family regulators and is the second ArsR regulator shown to be involved in biofilm formation.
DOI 10.1099/mic.0.058636-0
Grant Details