Peer-Reviewed Journal Details
Mandatory Fields
Muldowney, S,Lucey, AJ,Hill, TR,Seamans, KM,Taylor, N,Wallace, JMW,Horigan, G,Barnes, MS,Bonham, MP,Duffy, EM,Strain, JJ,Cashman, KD,Kiely, M
2012
January
The Journal of Nutrition
Incremental Cholecalciferol Supplementation up to 15 mu g/d Throughout Winter at 51-55 degrees N Has No Effect on Biomarkers of Cardiovascular Risk in Healthy Young and Older Adults
Validated
()
Optional Fields
VITAMIN-D SUPPLEMENTATION PLACEBO-CONTROLLED TRIAL DESCRIBING METABOLIC SYNDROME RANDOMIZED CONTROLLED-TRIAL PARATHYROID-HORMONE LEVELS BLOOD-PRESSURE INSULIN SENSITIVITY POSTMENOPAUSAL WOMEN 1,25-DIHYDROXYVITAMIN D-3 CALCIUM SUPPLEMENTATION
142
1519
1525
Two separate, identical, double-blind, randomized, placebo-controlled intervention studies were carried out in the south and north of Ireland (51-55 degrees N). Men and women aged 20-40 y (n = 202) and >= 64 y (n = 192) received cholecalciferol at doses of 0 (P), 5 (D3-5), 10 (D3-10), or 15 (D3-15) mu g/d (0-600 IU) during wintertime. Serum 25-hydroxyvitamin D [s25(OH)D], intact parathyroid hormone, systolic and diastolic blood pressure, fasting lipids, glucose and insulin, HOMA-IR, high-sensitivity CRP, matrix metalloproteinase-9, and its inhibitor (tissue inhibitor metalloproteinase-1) were measured at baseline (October) and 22 wk later at endpoint (March). Vitamin D receptor Fok I and Taq I genotypes were analyzed and dietary intakes of vitamin D and calcium were assessed. In young adults, s25(OH)D decreased from baseline to endpoint (P < 0.001), except in the D3-15 group, who maintained the baseline concentration of similar to 70 nmol/L. Older adults had lower s25(OH)D at baseline (median, 54.2 nmol/L) and concentrations increased in the D3-10 and D3-15 groups (P < 0.001). There were no significant effects of supplementation on cardiovascular disease (CVD) risk biomarkers in either age group. Fasting glucose and total and HDL cholesterol were lower (P< 0.05) in older adults with the Fok 1 ff genotype than in those with FF or Ff. Putative effects of vitamin D on cardio-metabolic health will only be evident at higher intakes than the current RDA and possibly in individuals at particular risk of low s25(OH)D and/or CVD risk. J. Nutr. 142: 1519-1525, 2012.
DOI 10.3945/jn.111.154005
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