Conference Publication Details
Mandatory Fields
Browne GM, Eustace JA, Perry IJ
Europrevent
Chronic Kidney Disease in Ireland
2012
May
Published
0
()
Optional Fields
                          

Background:
Chronic Kidney Disease (CKD) is an independent predictor for cardiovascular disease and is associated with hypertension, obesity, diabetes and age. This study describes stages of estimated glomerular filtration rate (eGFR) and albumin creatinine ratio (ACR) in Ireland. In Ireland at present the MDRD equation is universally used in clinical practice to estimate renal function. This is the first population based estimate in Ireland.

Methods: A population based cross-sectional study of adults was conducted using data from the 2007 Survey of Lifestyle, Attitudes and Nutrition (SLAN). A representative sample of 1,207 adults aged 45 and over, underwent a comprehensive physical examination including serum and urinalysis. Demographically this sample was similar to 2006 national census data. Using regression equations recalibrated MDRD and CKD-EPI, eGFR was calculated from a single serum creatinine. Spot Urine Albumin Creatinine ratio (ACR mg/g) was measured.

Results: eGFR <60 ml/min/1.73 m2 based on the CKD-EPI regression equation occurred in 12.1% (95%CI 10.3-14%). ACR >30mg/g occurred in 13.2% (95%CI 11.2-15.2%). ACR >30mg/g varied from 11.1% in GFR Stage 1 to 100% in GFR stage 4-5. Using the MDRD equation, more subjects were categorised as eGFR<60, and similarly more subjects were described as GFR Stage 2 compared to GFR Stage 1 (Table 1). Younger and female subjects were more likely to be categorised as a lower GFR using the MDRD equation.

Conclusions: Lower estimates of GFR, which may be dependent on the method of estimation, can impact on the individual and their risk profile. The MDRD equation has widespread use in Ireland and in the UK. The CKD-EPI formula results in higher estimated GFR. Albuminuria, as an additional measure of cardiovascular risk, is prevalent in this population.

GFR Stages (G1-5) by CKD-EPI & MDRD

ALL N=1160* (95%CI)

GFR Stages

CKD-EPI

MDRD

G1

33.2% (30.9, 36.3%)

19.2% (17, 21.5%)

G2

54.22% (51.4, 57.1%)

65.5% (62.8, 68.3%)

G3A

9.22% (7.6, 10.9%)

11.98% (10.1, 13.9%)

G3B

2.5% (1.6, 3.4%)

2.84% (1.9, 3.8%)

G4-5

0.43% (0.05, 0.8%)

0.43% (0.05, 0.8%)

*Subjects with an available serum creatinine

Grant Details