Bravo, JA,Julio-Pieper, M,Forsythe, P,Kunze, W,Dinan, TG,Bienenstock, J,Cryan, JF

2012

January

Current Opinion In Pharmacology

Communication between gastrointestinal bacteria and the nervous system

Validated

()

IRRITABLE-BOWEL-SYNDROME ANXIETY-LIKE BEHAVIOR GUT-BRAIN COMMUNICATION LACTOBACILLUS-REUTERI GERM-FREE MATERNAL SEPARATION MICE BIFIDOBACTERIUM MICROBIOTA RATS

12

667

672

In the past few years, intestinal microbiota has emerged as a novel target for the treatment of gut-brain axis alterations. These include functional gastrointestinal disorders, such as irritable bowel syndrome (IBS), which can be comorbid with stress-related psychiatric conditions. Thus, modulation of the microbiota (e.g. with the use of probiotics) could be proposed as a novel strategy not only for the treatment of IBS but also as an adjuvant for psychiatric treatment of anxiety and depression.

DOI 10.1016/j.coph.2012.09.010