Peer-Reviewed Journal Details
Mandatory Fields
Dwyer, M. P.,Paruch, K.,Alvarez, C.,Doll, R. J.,Keertikar, K.,Duca, J.,Fischmann, T. O.,Hruza, A.,Madison, V.,Lees, E.,Parry, D.,Seghezzi, W.,Sgambellone, N.,Shanahan, F.,Wiswell, D.,Guzi, T. J.
2007
November
Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors
Validated
()
Optional Fields
17
2222
6216
62196216
A series of four bicyclic cores were prepared and evaluated as cyclin-dependent kinase-2 (CDK2) inhibitors. From the invitro and cell-based analysis, the pyrazolo[1,5-a]pyrimidine core (represented by 9) emerged as the superior core for further elaboration in the identification of novel CDK2 inhibitors. (C) 2007 Elsevier Ltd. All rights reserved.A series of four bicyclic cores were prepared and evaluated as cyclin-dependent kinase-2 (CDK2) inhibitors. From the invitro and cell-based analysis, the pyrazolo[1,5-a]pyrimidine core (represented by 9) emerged as the superior core for further elaboration in the identification of novel CDK2 inhibitors. (C) 2007 Elsevier Ltd. All rights reserved.
0960-894X0960-894X
://WOS:000250906200035://WOS:000250906200035
Grant Details