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Mandatory Fields
Reviews
Hennessy, AA,Ross, RP,Devery, R,Stanton, C
2011
February
The Health Promoting Properties of the Conjugated Isomers of alpha-Linolenic Acid
Validated
1
WOS: 99 ()
Optional Fields
CLA Catalpic Eleostearic Calendic Punicic Cancer Obesity Atherosclerosis Inflammation CORONARY-HEART-DISEASE HUMAN BREAST-CANCER HUMAN TUMOR-CELLS SEED OIL-RICH PROINFLAMMATORY CYTOKINE PRODUCTION OCTADECATRIENOIC FATTY-ACID POMEGRANATE PUNICA-GRANATUM NF-KAPPA-B PROSTATE-CANCER LIPID-PEROXIDATION
The bioactive properties of the conjugated linoleic acid (CLA) isomers have long been recognised and are the subject of a number of excellent reviews. However, despite this prominence the CLA isomers are not the only group of naturally occurring dietary conjugated fatty acids which have shown potent bioactivity. In a large number of in vitro and in vivo studies, conjugated alpha-linolenic acid (CLNA) isomers have displayed potent anti-inflammatory, immunomodulatory, anti-obese and anti-carcinogenic activity, along with the ability to improve biomarkers of cardio-vascular health. CLNA isomers are naturally present in high concentrations in a large variety of seed oils but can also be produced in vitro by strains of lactobacilli and bifidobactena through the activity of the enzyme linoleic acid isomerase on alpha-linolenic acid. In this review, we will address the possible therapeutic roles that CLNA may play in a number of conditions afflicting Western society and the mechanisms through which this activity is mediated.
105
119
10.1007/s11745-010-3501-5
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