Peer-Reviewed Journal Details
Mandatory Fields
Slattery, DA,Neumann, ID,Cryan, JF
2011
October
Journal of psychopharmacology (Oxford, England)
Transient inactivation of the infralimbic cortex induces antidepressant-like effects in the rat
Validated
Optional Fields
Cingulate depression forced swim test inactivation neuroimaging trait anxiety MEDIAL PREFRONTAL CORTEX ANXIETY-RELATED BEHAVIOR FORCED SWIMMING TEST C-FOS EXPRESSION MAJOR DEPRESSION FEAR EXTINCTION TRAIT ANXIETY ANIMAL-MODEL PREPULSE INHIBITION MOOD DISORDERS
25
1295
1303
Affective disorders are among the main causes of disability worldwide, yet the underlying pathophysiology remains poorly understood. Recently, Landmark neuroimaging studies have shown increased metabolic activity in Brodmann Area 25 (BA25) in depressed patients. Moreover, functional inactivation of this region using deep brain stimulation alleviated depressive symptoms in severely depressed patients. Thus, we examined the effect of a similar manipulation, pharmacological inactivation of the infralimbic cortex, the rodent correlate of BA25, in an animal model of antidepressant activity: the modified rat forced swim test. Transient inactivation of the infralimbic cortex using muscimol reduced immobility, an antidepressant-like effect in the test. Importantly, this activity was not the result of a general increase in locomotor activity. Activation of the infralimbic cortex using bicuculline did not alter behaviour. Finally, we examined the effect of muscimol in animals bred for high anxiety-related behaviour, which also display elevated depression-related behaviour. Transient inactivation of the infralimbic cortex decreased the high inborn depression-like behaviour of these rats. These results show that it is possible to replicate findings from a clinical trial in a rodent model. Further, they support the use of the forced swim test to gain greater understanding of the neurocircuitry involved in depression and antidepressant-action.
10.1177/0269881110368873
Grant Details