Turroni, F,Taverniti, V,Ruas-Madiedo, P,Duranti, S,Guglielmetti, S,Lugli, GA,Gioiosa, L,Palanza, P,Margolles, A,van Sinderen, D,Ventura, M

2014

January

Applied and Environmental Microbiology

Bifidobacterium bifidum PRL2010 Modulates the Host Innate Immune Response

Validated

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HEAT-SHOCK PROTEINS INTESTINAL EPITHELIAL-CELLS CACO-2 CELLS GENE-EXPRESSION IN-VITRO LACTOBACILLUS-ACIDOPHILUS COLORECTAL-CARCINOMA ULCERATIVE-COLITIS DENDRITIC CELLS GENOME ANALYSIS

80

730

740

Here, we describe data obtained from transcriptome profiling of human cell lines and intestinal cells of a murine model upon exposure and colonization, respectively, with Bifidobacterium bifidum PRL2010. Significant changes were detected in the transcription of genes that are known to be involved in innate immunity. Furthermore, results from enzyme-linked immunosorbent assays (ELISAs) showed that exposure to B. bifidum PRL2010 causes enhanced production of interleukin 6 (IL-6) and IL-8 cytokines, presumably through NF-kappa B activation. The obtained global transcription profiles strongly suggest that Bifidobacterium bifidum PRL2010 modulates the innate immune response of the host.

10.1128/AEM.03313-13