Guinane, CM,Cotter, PD,Lawton, EM,Hill, C,Ross, RP

2007

July

Applied and Environmental Microbiology

Insertional mutagenesis to generate lantibiotic resistance in Lactococcus lactis

Validated

()

BROAD-SPECTRUM BACTERIOCIN LISTERIA-MONOCYTOGENES NISIN RESISTANCE ACID BACTERIA SYSTEM SENSITIVITY EXPRESSION TOLERANCE VIRULENCE SEQUENCE

73

4677

4680

While the potential emergence of food spoilage and pathogenic bacteria with resistance to lantibiotics is a concern, the creation of derivatives of starter cultures and adjuncts that can grow in the presence of these antimicrobials may have applications in food fermentations. Here a bank of Lactococcus lactis IL1403 mutants was created and screened, and a number of novel genetic loci involved in lantibiotic resistance were identified.

10.1128/AEM.02351-06