Mathur, H,O'Connor, PM,Hill, C,Cotter, PD,Ross, RP

2013

June

Antimicrobial Agents and Chemotherapy

Analysis of Anti-Clostridium difficile Activity of Thuricin CD, Vancomycin, Metronidazole, Ramoplanin, and Actagardine, both Singly and in Paired Combinations

Validated

WOS: 34 ()

IN-VITRO NARROW-SPECTRUM INFECTION DISEASES SUSCEPTIBILITY SYNERGY SOCIETY COLONIZATION RECURRENCE GUIDELINES

57

2882

2886

Due to the ongoing problem of recurrence of Clostridium difficile-associated diarrhea following antibiotic treatment, there is an urgent need for alternative treatment options. We assessed the MICs of five antimicrobials singly and in combinations against a range of C. difficile clinical isolates. Ramoplanin-actagardine combinations were particularly effective, with partial synergistic/additive effects observed against 61.5% of C. difficile strains tested.

10.1128/AAC.00261-13