Peer-Reviewed Journal Details
Mandatory Fields
Mathur, H,O'Connor, PM,Hill, C,Cotter, PD,Ross, RP
2013
June
Antimicrobial Agents and Chemotherapy
Analysis of Anti-Clostridium difficile Activity of Thuricin CD, Vancomycin, Metronidazole, Ramoplanin, and Actagardine, both Singly and in Paired Combinations
Validated
WOS: 28 ()
Optional Fields
IN-VITRO NARROW-SPECTRUM INFECTION DISEASES SUSCEPTIBILITY SYNERGY SOCIETY COLONIZATION RECURRENCE GUIDELINES
57
2882
2886
Due to the ongoing problem of recurrence of Clostridium difficile-associated diarrhea following antibiotic treatment, there is an urgent need for alternative treatment options. We assessed the MICs of five antimicrobials singly and in combinations against a range of C. difficile clinical isolates. Ramoplanin-actagardine combinations were particularly effective, with partial synergistic/additive effects observed against 61.5% of C. difficile strains tested.
10.1128/AAC.00261-13
Grant Details