Peer-Reviewed Journal Details
Mandatory Fields
Hill, T,Meunier, N,Andriollo-Sanchez, M,Ciarapica, D,Hininger-Favier, I,Polito, A,O'Connor, JM,Coudray, C,Cashman, KD
2005
November
European Journal of Clinical Nutrition
The relationship between the zinc nutritive status and biochemical markers of bone turnover in older European adults: the ZENITH study
Validated
WOS: 29 ()
Optional Fields
zinc intake and status bone turnover MINERAL CONTENT DIETARY-INTAKE WOMEN OSTEOPOROSIS RESORPTION METABOLISM COPPER
59
73
78
Objective: To investigate the relationship between indices of zinc nutritive status and biochemical markers of bone turnover in older adult European subjects.Design: Use of baseline data from a multicentre prospective zinc intervention (ZENITH) study.Setting: Centres in France, Italy and Northern Ireland.Participants: A total of 387 healthy adults, aged 55-87 y.Methods: Zinc intake was assessed by 4-day recall records. Circulating and urinary biochemical zinc status measures were assessed by atomic absorption spectrophometry. Serum bone-specific alkaline phosphatase and osteocalcin were assessed by ELISA and urinary pyridinoline (Pyr) and deoxypyridinoline (Dpyr) by HPLC.Results: Zinc intake was negatively correlated with urinary Pyr and Dpyr (r= -0.298 and -0.304, respectively; P<0.0001), but was not correlated with bone formation markers. There was a tendency for serum zinc to be negatively correlated with urinary Dpyr (r= -0.211; P = 0.080). Erythrocyte zinc was negatively correlated with serum osteocalcin (r= -0.090; P<0.0001). None of the other correlations were significant. After adjustment for confounder (age, gender and research Centre) the only significant association that remained was between serum osteocalcin and erythrocyte zinc (P = -0.124; P=0.011).Conclusions: There was some, albeit inconsistent, evidence of a relationship between zinc nutritive status and bone turnover in the older adult participants of the ZENITH study.
10.1038/sj.ejcn.1602303
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