Peer-Reviewed Journal Details
Mandatory Fields
Slattery, CN,Maguire, AR
2013
May
Tetrahedron Letters
Copper-catalysed enantioselective intramolecular C-H insertion reactions of alpha-diazo-beta-keto esters and alpha-diazo-beta-keto phosphonates
Validated
WOS: 14 ()
Optional Fields
Diazocarbonyl C-H insertion Copper catalysis Bis(oxazoline) NaBARF DIAZOCARBONYL COMPOUNDS CARBENOID REACTIONS DECOMPOSITION DIAZOSULFONES CARBOXYLATES SUBSTITUENT YLIDES BONDS
54
2799
2801
Copper-catalysed intramolecular C-H insertion reactions of alpha-diazo-beta-keto esters and alpha-diazo-beta-keto phosphonates are described, with moderate-to-good levels of enantioselectivity achieved for reactions employing the borate additive sodium tetrakis[3,5-bis(trifluoromethyl)phenyl]borate (NaBARF). Notably, the first example of asymmetric induction reported to date for intramolecular C-H insertion of an alpha-diazo-beta-keto phosphonate is also described. (C) 2013 Elsevier Ltd. All rights reserved.
10.1016/j.tetlet.2013.03.078
Grant Details