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Chia, TY,Sattar, MA,Abdulla, MH,Johns, EJ
2011
November
Healthmed
The effect of Cyclosporine-a on the renal vascular response to ANG II and Adrenegic Agonist in Sprague-Dawley rat
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alpha(1-)adrenoceptor; cyclosporine A; noradrenaline renal failure Sprague-Dawley rats ANGIOTENSIN-II HYPERTENSIVE-RATS ALPHA(1)-ADRENOCEPTOR SUBTYPES CELLULAR MECHANISMS OXIDATIVE STRESS FAILURE KIDNEY VASOCONSTRICTION NEPHROTOXICITY INJURY
5
1857
1867
Background: The present study investigates the effect of cyclosporine A (CsA) on renal haemodynamics and excretory functions.Methods: Sprague-Dawley rats received CsA for 21 days at (25 mg/kg/day) p.o. The renal cortical vasoconstriction to noradrenaline, phenylephrine, methoxamine and angiotensin II was done at the end of treatment period. Data, mean +/- SEM were analyzed by ANOVA with significance at p<0.05.Results: CsA treated rats showed significant reduction in body weight, fluid intake, creatinine clearance, glomerular filtration rate, fractional sodium and potassium excretion with an elevation in blood pressure and urinary protein excretion compared to control. The renal vasoconstriction due to adrenergic agonists and angiotensin II was blunted although significant only for noradrenaline and angiotensin II in CsA treated group compared to control.Conclusion: These findings suggest an attenuation of AT(1) or alpha(1)-adrenoceptors response to angiotensin II and adrenergic stimuli possibly due to higher sympathetic and renin-angiotensin systems activity in CsA-induced renal failure model.
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