Peer-Reviewed Journal Details
Mandatory Fields
Pereira-Fantini PM, Lapthorne S, Joyce SA, Dellios NL, Wilson G, Fouhy F, Thomas SL, Scurr M, Hill C, Gahan CG, Cotter PD, Fuller PJ, Hardikar W, Bines JE
2014
July
Journal of hepatology
Altered FXR signaling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease.
Validated
Optional Fields
Despite the mortality associated with liver disease observed in patients with short bowel syndrome (SBS), mechanisms underlying the development of SBS-associated liver disease (SBS-ALD) are poorly understood. This study examines the impact of bacterially-mediated bile acid (BA) dysmetabolism on FXR signaling pathways and clinical outcome in a piglet model of SBS-ALD.
10.1016/j.jhep.2014.06.025
Grant Details