O'Malley D, Buckley MM, McKernan DP, Quigley EM, Cryan JF, Dinan TG

2014

August

Brain Behav Immun

Soluble mediators in plasma from irritable bowel syndrome patients excite rat submucosal neurons.

Validated

WOS: 12 ()

Episodic bouts of abdominal pain and altered bowel habit are characteristic of irritable bowel syndrome (IBS). Although a comprehensive understanding of IBS pathophysiology remains elusive, support is growing for a primary role for immune activation in disease severity as evidenced by altered cytokine profiles in IBS plasma. Additionally, aberrant stimulation of the stress axis is likely to result in altered plasma constituents.

10.1016/j.bbi.2014.08.005