Peer-Reviewed Journal Details
Mandatory Fields
O'Malley D, Buckley MM, McKernan DP, Quigley EM, Cryan JF, Dinan TG
2014
August
Brain Behav Immun
Soluble mediators in plasma from irritable bowel syndrome patients excite rat submucosal neurons.
Validated
WOS: 11 ()
Optional Fields
Episodic bouts of abdominal pain and altered bowel habit are characteristic of irritable bowel syndrome (IBS). Although a comprehensive understanding of IBS pathophysiology remains elusive, support is growing for a primary role for immune activation in disease severity as evidenced by altered cytokine profiles in IBS plasma. Additionally, aberrant stimulation of the stress axis is likely to result in altered plasma constituents.
10.1016/j.bbi.2014.08.005
Grant Details