Peer-Reviewed Journal Details
Mandatory Fields
Deasy, RE,Maguire, AR
2014
June
European Journal of Organic Chemistry
Baker's-Yeast-Mediated Reduction of Sulfur-Containing Compounds
Validated
Scopus: 9 ()
Optional Fields
Synthetic methods Enzyme catalysis Biotransformations Reduction Enantioselectivity Chiral alcohols Sulfur EFFICIENT ASYMMETRIC OXIDATION BIOLOGICALLY-ACTIVE COMPOUNDS BIFUNCTIONAL CHIRAL SYNTHONS ACID-CATALYZED CYCLIZATION HIGH OPTICAL PURITY ENANTIOSELECTIVE SYNTHESIS MICROBIAL REDUCTION STEREOSELECTIVE-SYNTHESIS SACCHAROMYCES-CEREVISIAE KINETIC RESOLUTION
2014
3737
3756
Both the efficiency and the stereoselectivity in baker's-yeast-mediated reduction of ketones are strongly influenced by both the presence and the position of sulfur substituents, or indeed by the use of sulfur-containing additives. Interestingly the oxidation level of the sulfur substituent has a powerful impact on the outcome of the yeast reduction. It is apparent that use of the sulfone moiety as a substituent to influence the efficiency and stereoselectivity in ketone reduction is substantially more effective than use of the analogous sulfide and sulfoxide moieties.
10.1002/ejoc.201301729
Grant Details