Reviews

Clarke, G,O'Mahony, SM,Dinan, TG,Cryan, JF

2014

August

Priming for health: gut microbiota acquired in early life regulates physiology, brain and behaviour

Validated

1

Altmetric: 18 ()

Behaviour Brain Development Breastfeeding Early Life Microbiota INTESTINAL MICROBIOTA IMMUNE-SYSTEM HUMAN-MILK MATERNAL SEPARATION STRESS-RESPONSE INFANTS IMPACT MICE DYSFUNCTION PROBIOTICS

The infant gut microbiome is dynamic, and radical shifts in composition occur during the first 3 years of life. Disruption of these developmental patterns, and the impact of the microbial composition of our gut on brain and behaviour, has attracted much recent attention. Integrating these observations is an important new research frontier.Conclusion: Early-life perturbations of the developing gut microbiota can impact on the central nervous system and potentially lead to adverse mental health outcomes.

812

819

10.1111/apa.12674