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O'Callaghan, Y,McCarthy, FO,O'Brien, NM
2014
April
Recent advances in Phytosterol Oxidation Products
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Phytosterols beta-Sitosterol Stigmasterol Campesterol Dihydrobrassicasterol Phytosterol Oxidation Products Atherosclerosis Toxicity Oxidative stress Cholesterol absorption BETA-SITOSTEROL OXIDIZED DERIVATIVES PLANT STEROLS COLON-CANCER CHOLESTEROL OXIDES CELLS OXYPHYTOSTEROL CAMPESTEROL APOPTOSIS
Phytosterols and their oxidation products have become increasingly investigated in recent years with respect to their roles in diet and nutrition. We present a comprehensive review of recent literature on Phytosterol Oxidation Products (POP) identifying critical areas for future investigation. It is evident that POP are formed on food storage/preparation; are absorbed and found in human serum; do not directly affect cholesterol absorption; have evidence of atherogenicity and inflammation; have distinct levels of cytotoxicity; are implicated with high levels of oxidative stress, glutathione depletion, mitochondrial dysfunction and elevated caspase activity. (C) 2014 Elsevier Inc. All rights reserved.
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10.1016/j.bbrc.2014.01.148
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