Other Publication Details
Mandatory Fields
Reviews
Bane, V,Lehane, M,Dikshit, M,O'Riordan, A,Furey, A
2014
February
Tetrodotoxin: Chemistry, Toxicity, Source, Distribution and Detection
Validated
1
Optional Fields
toxicity detection TTX source TTX analogues chemistry tetrodotoxin distribution MARINE GASTROPOD NASSARIUS TANDEM MASS-SPECTROMETRY RED-SPOTTED NEWT PARALYTIC SHELLFISH TOXINS FRESH-WATER PUFFERS LAGOCEPHALUS-SCELERATUS GMELIN OPTICALLY-ACTIVE TETRODOTOXIN FROG BRACHYCEPHALUS-EPHIPPIUM EFFICIENT TOTAL-SYNTHESIS FISH FUGU-RUBRIPES
Tetrodotoxin (TTX) is a naturally occurring toxin that has been responsible for human intoxications and fatalities. Its usual route of toxicity is via the ingestion of contaminated puffer fish which are a culinary delicacy, especially in Japan. TTX was believed to be confined to regions of South East Asia, but recent studies have demonstrated that the toxin has spread to regions in the Pacific and the Mediterranean. There is no known antidote to TTX which is a powerful sodium channel inhibitor. This review aims to collect pertinent information available to date on TTX and its analogues with a special emphasis on the structure, aetiology, distribution, effects and the analytical methods employed for its detection.
693
755
10.3390/toxins6020693
Grant Details