Deasy, RE,O'Riordan, N,Maguire, AR

2014

June

Catalysts

Baker's Yeast Mediated Reduction of 2-Acetyl-3-methyl Sulfolane

Validated

WOS: 4 ()

baker's yeast (Saccharomyces cerevisiae) biocatalysis asymmetric reduction chiral alcohol sulfolane HIV-1 PROTEASE INHIBITORS ASYMMETRIC REDUCTION STEREOCHEMICAL CONTROL CYCLIC SULFONES 3-OXO ESTERS

4

186

195

The baker's yeast mediated reduction of 2-acetyl-3-methyl sulfolane 1 to provide the corresponding alcohol 2 is described. Excellent efficiency and enantioselectivity (>98% ee) has been achieved under these mild environmentally benign reaction conditions. In direct contrast, the chemical reduction of 1 proceeds with poor yield (<= 25%) and diastereocontrol.

10.3390/catal4020186