Clarke, SL,McSweeney, CM,McGlacken, GP

2014

February

Tetrahedron-Asymmetry

Investigation of a novel diamine based chiral auxiliary in the asymmetric alkylation of ketones

Validated

WOS: 5 ()

IONOPHORE ANTIBIOTIC X-14547A CYCLIC CARBAMATE HYDRAZONES ALPHA-ALKYLATION ACYCLIC KETONES PROLINE ALPHA,ALPHA-BISALKYLATION TETRAHYDROPYRAN DERIVATIVES EFFICIENT

25

356

361

A novel chiral auxiliary containing a pyrrolidine ring has been utilised in the preparation of various chiral ketones with good to excellent enantioselectivities (up to 92%). It has been successfully employed in aldol and Michael reactions giving moderate to high selectivity. (C) 2014 Elsevier Ltd. All rights reserved.

10.1016/j.tetasy.2014.01.006