ABSTRACT Abstract Re-emerging syphilis outbreaks across Europe have led to increasing syphilis rates among women of childbearing age. We therefore identified all forms of syphilis cases among women hospitalized for delivery in Ireland over a six-year period. Cases per annum ranged from 10 to 24 (13.8 to 32.9 per 100,000 maternities). Rates of syphilis in this universally screened cohort were four times higher than the general Irish population. Future studies examining the incidence of congenital syphilis as well as patterns in follow-up treatment for the sero-positive mother and her infant are needed to better guide clinical intervention.