Clarke, Gerard,O'Mahony, Siobhain M.,Hennessy, Alan A.,Ross, Paul,Stanton, Catherine,Cryan, John F.,Dinan, Timothy G.

2009

December

Behavioural Brain Researchbehavioural Brain Research

Chain reactions: Early-life stress alters the metabolic profile of plasma polyunsaturated fatty acids in adulthood

Validated

()

205

11

319

321

The rat maternal separation paradigm can be used to examine the biological consequences of early-life stress. Immunomodulatory polyunsaturated fatty acids (PUFAs) have recently attracted attention in the study of stress-related disorders. We established the plasma PUFA profile of maternally separated rodents compared to controls. Our results identify a proinflammatory PUFA profile as a persistent consequence of early-life stress and suggest new avenues of investigation in stress-related disorders. (C) 2009 Elsevier B.V. All rights reserved.The rat maternal separation paradigm can be used to examine the biological consequences of early-life stress. Immunomodulatory polyunsaturated fatty acids (PUFAs) have recently attracted attention in the study of stress-related disorders. We established the plasma PUFA profile of maternally separated rodents compared to controls. Our results identify a proinflammatory PUFA profile as a persistent consequence of early-life stress and suggest new avenues of investigation in stress-related disorders. (C) 2009 Elsevier B.V. All rights reserved.

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