Wortmann, L.; Ilyas, S.; Niznansky, D.; Valldor, M.; Arroub, K.; Berger, N.; Rahme, K.; Holmes, J.; Mathur, S.

2014

October

Acs Applied Materials & Interfaces

Bioconjugated iron oxide nanocubes: synthesis, functionalization, and vectorization

Published

Altmetric: 1 ()

6

19

16631

16642

A facile bottom-up approach for the synthesis of inorganic/organic bioconjugated nanoprobes based on iron oxide nanocubes as the core with a nanometric silica shell is demonstrated. Surface coating and functionalization protocols developed in this work offered good control over the shell thickness (8−40 nm) and enabled biovectorization of SiO2@Fe3O4 core−shell structures by covalent attachment of folic acid (FA) as a targeting unit for cellular uptake. The successful immobilization of folic acid was investigated both quantitatively (TGA, EA, XPS) and qualitatively (AT-IR, UV−vis, ζ- potential). Additionally, the magnetic behavior of the nanocomposites was monitored after each functionalization step. Cell viability studies confirmed low cytotoxicity of FA@SiO2@Fe3O4 conjugates, which makes them promising nanoprobes for targeted internalization by cells and their imaging.

Washington, DC, USA

http://pubs.acs.org/journal/aamick

10.1021/am503068r