Said JM, Tsui R, Borg AJ, Higgins JR, Moses EK, Walker SP, Monagle PT, Brennecke SP

2012

May

Journal of Thrombosis and Haemostasis

The PAI-1 4G/5G polymorphism is not associated with an increased risk of adverse pregnancy outcome in asymptomatic nulliparous women.

Validated

()

10

5

881

886

Plasminogen activator inhibitor type 1 (PAI-1) is an important regulator of fibrinolysis. A common deletion polymorphism that results in a sequence of 4G instead of 5G in the promoter region of the gene is associated with a small increase in the risk of venous thromboembolism. Its potential association with adverse pregnancy events remains controversial.

10.1111/j.1538-7836.2012.04700.x