Peer-Reviewed Journal Details
Mandatory Fields
Donovan MD, O'Brien FE, Boylan GB, Cryan JF, Griffin BT
2015
April
The Journal of pharmacy and pharmacology
The effect of organic anion transporter 3 inhibitor probenecid on bumetanide levels in the brain: an integrated in vivo microdialysis study in the rat.
Published
Optional Fields
Recent data highlight the potential of bumetanide as a treatment for neonatal seizures and autism, as it facilitates the excitatory to inhibitory switch in gamma-aminobutyric acid signalling. This study examines the extent of blood-brain barrier (BBB) permeation of bumetanide, a key determinant of the efficacy of centrally acting drugs. Furthermore, the impact of efflux transporter organic anion transporter 3 (oat3) inhibition on bumetanide pharmacokinetics was investigated.
10.1111/jphp.12341
Grant Details