Peer-Reviewed Journal Details
Mandatory Fields
Hegarty, SV, O'Keeffe, GW*, Sullivan, AM.*
2014
October
Neural Regeneration Research
Neurotrophic factors: from neurodevelopmental regulators to novel therapies for Parkinson's disease
Published
()
Optional Fields
Parkinson's disease; glial cell line-derived neurotrophic factor; growth/differentiation factor 5; nervous system development; neuroprotection; neurotrophic factors; neurturin; nigrostriatal dopaminergic neurons
9
19
1708
1711
Neuroprotection and neuroregeneration are two of the most promising disease-modifying therapies for the incurable and widespread Parkinson's disease. In Parkinson's disease, progressive degeneration of nigrostriatal dopaminergic neurons causes debilitating motor symptoms. Neurotrophic factors play important regulatory roles in the development, survival and maintenance of specific neuronal populations. These factors have the potential to slow down, halt or reverse the loss of nigrostriatal dopaminergic neurons in Parkinson's disease. Several neurotrophic factors have been investigated in this regard. This review article discusses the neurodevelopmental roles and therapeutic potential of three dopaminergic neurotrophic factors: glial cell line-derived neurotrophic factor, neurturin and growth/differentiation factor 5.
9 (19)
10.4103/1673-5374.143410.
Grant Details