Peer-Reviewed Journal Details
Mandatory Fields
O'Keeffe, G.W., Hanke, M., Pohl, J., Sullivan, A.M.
2004
July
Brain research. Developmental brain research
Expression of growth differentiation factor-5 in the developing and adult rat brain.
Validated
()
Optional Fields
151
1-2
199
202
Expression of the dopaminergic neurotrophin GDF-5 in developing rat ventral mesencephalon (VM) was found to begin at embryonic day (E) 12 and peak on E14, when dopaminergic neurones undergo terminal differentiation. In the adult rat, GDF-5 was found to be restricted to heart and brain, being expressed in many areas of the brain, including striatum and midbrain. This indicates a role for GDF-5 in the development and maintenance of dopaminergic neurones.
10.1016/j.devbrainres.2004.04.004
Grant Details