Peer-Reviewed Journal Details
Mandatory Fields
Strelau, J., Bottner, M., Lingor, P., Suter-Crazzolara, C., Galter, D., Jaszai, J., Sullivan, A., Schober, A., Krieglstein, K., Unsicker, K.
2000
January
Journal of neural transmission. Supplementum
GDF-15/MIC-1 a novel member of the TGF-beta superfamily.
Validated
()
Optional Fields
60
273
276
We have cloned, expressed, and raised antibodies against a novel member of the TGF-beta superfamily, growth/differentiation factor-15 (GDF-15). The predicted protein is identical to macrophage inhibitory cytokine-1 (MIC-1), which was discovered simultaneously. GDF-15 is a more distant member of the TGF-beta superfamily and does not belong to one of the known TGF-beta subfamilies. In the CNS, GDF-15/MIC-1 mRNA is abundantly expressed by the choroid plexus. In addition we have preliminary evidence that GDF-15/MIC-1 is a potent trophic factor for selected classes of neurons in vitro and in vivo. Thus, GDF-15 is a novel neurotrophic factor with prospects for the treatment of disorders of the CNS.
Grant Details