Peer-Reviewed Journal Details
Mandatory Fields
Sullivan, A.M. Reynolds, D.S., Thomas, K.L., Morton, A.J.
1996
December
Neuroreport
Cortical induction of c-fos by intrastriatal endothelin-1 is mediated via NMDA receptors.
Validated
()
Optional Fields
8
1
211
216
Endothelin (ET) is a potent vasoconstrictor which has also been proposed to act as a neuromodulator. We have investigated the action of ET-1 on neurones in vivo, using c-fos as a marker of neuronal activation. Intrastriatal injection of ET-1 caused seizures and barrel rolling which were prevented by pretreatment with the N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 and attenuated by the nitric-oxide synthase inhibitor N omega-nitro-L-arginine (L-NNA). In association with these behaviours, a dramatic increase in c-fos mRNA expression was seen in the cerebral cortex. This increase was blocked by both MK-801 and L-NNA. We suggest that ET-1 modulates the activity of cortical afferents to the striatum, and causes seizures via an NMDA receptor-dependent mechanism.
Grant Details