Peer-Reviewed Journal Details
Mandatory Fields
Jennifer Manning and Dervla O'Malley
Journal of Muscle Research and Cell Motility
What has the mdx mouse contributed to our understanding of Duchenne Muscular Dystrophy?
In Press
Optional Fields
Duchenne Muscular Dystrophy (DMD) is a fatal X-chromosome linked recessive disorder caused by the truncation or deletion of the dystrophin gene. The most widely used animal model of this disease is the dystrophin-deficient mdx mouse which was first discovered thirty years ago. Despite its extensive use in DMD research, no effective treatment has yet been developed for this devastating disease. This review explores what we have learned from this mouse model regarding the pathophysiology of DMD and asks if it has a future in providing a better more thorough understanding of this disease or if it will bring us any closer to improving the outlook for DMD patients.
Grant Details