Peer-Reviewed Journal Details
Mandatory Fields
Mayer EA, Knight R, Mazmanian SK, Cryan JF, Tillisch K
2014
November
The Journal of neuroscience : the official journal of the Society for Neuroscience
Gut microbes and the brain: paradigm shift in neuroscience.
Validated
Optional Fields
34
46
15490
15496
The discovery of the size and complexity of the human microbiome has resulted in an ongoing reevaluation of many concepts of health and disease, including diseases affecting the CNS. A growing body of preclinical literature has demonstrated bidirectional signaling between the brain and the gut microbiome, involving multiple neurocrine and endocrine signaling mechanisms. While psychological and physical stressors can affect the composition and metabolic activity of the gut microbiota, experimental changes to the gut microbiome can affect emotional behavior and related brain systems. These findings have resulted in speculation that alterations in the gut microbiome may play a pathophysiological role in human brain diseases, including autism spectrum disorder, anxiety, depression, and chronic pain. Ongoing large-scale population-based studies of the gut microbiome and brain imaging studies looking at the effect of gut microbiome modulation on brain responses to emotion-related stimuli are seeking to validate these speculations. This article is a summary of emerging topics covered in a symposium and is not meant to be a comprehensive review of the subject.
10.1523/JNEUROSCI.3299-14.2014
Grant Details